Glutaraldehyde Technological Frontier: Tshaj tawm hauv Kev Siv Hluav Taws Xob Hluav Taws Xob

Hauv kev cog cov hlab plawv, glutaraldehyde tau ntev tau siv los kho tsiaj cov ntaub so ntswg (xws li bovine pericardium) rau kev tsim cov bioprosthetic li qub. Txawm li cas los xij, cov seem dawb aldehyde pawg los ntawm cov txheej txheem ib txwm muaj tuaj yeem ua rau tom qab cog calcification, cuam tshuam rau lub sijhawm ntev ntawm cov khoom.

Hais txog qhov kev sib tw no, ib txoj kev tshawb fawb tshiab tshaj tawm hauv lub Plaub Hlis 2025 tau qhia txog cov tshuaj tiv thaiv calcification tshiab (cov khoom npe: Periborn), ua tiav qhov kev vam meej.

1.Core Technological Upgrades:

Qhov kev daws teeb meem no qhia txog ntau qhov kev txhim kho tseem ceeb rau cov txheej txheem glutaraldehyde hla kev sib txuas:

Organic Solvent Cross-Linking:
Glutaraldehyde cross-linking yog ua nyob rau hauv cov organic hnyav uas muaj li ntawm 75% ethanol + 5% octanol. Txoj hauv kev no pab tshem tawm cov ntaub so ntswg phospholipids zoo dua thaum lub sijhawm sib txuas-phospholipids yog thawj qhov chaw nucleation rau calcification.

Space-Filling Agent:

Tom qab kev sib txuas ntawm kev sib txuas, polyethylene glycol (PEG) yog siv los ua qhov chaw ntim khoom, infiltrating qhov khoob ntawm collagen fibers. Qhov no ob leeg tiv thaiv qhov chaw nucleation ntawm hydroxyapatite muaju thiab tiv thaiv kev nkag mus ntawm calcium thiab phospholipids los ntawm cov tswv plasma.

Terminal Sealing:

Thaum kawg, kev kho mob nrog glycine neutralizes residual, reactive dawb aldehyde pawg, yog li tshem tawm lwm yam tseem ceeb uas ua rau calcification thiab cytotoxicity.

2. Cov txiaj ntsig kho mob tau zoo:

Cov thev naus laus zis no tau siv rau lub pob zeb pericardial scaffold hu ua "Periborn." Ib txoj kev tshawb nrhiav kev soj ntsuam uas suav nrog 352 tus neeg mob ntau dua 9 xyoo tau pom tias muaj kev ywj pheej los ntawm kev rov ua haujlwm dua vim yog cov teeb meem cuam tshuam txog cov khoom lag luam siab txog 95.4%, lees paub qhov ua tau zoo ntawm cov tswv yim tshiab los tiv thaiv calcification thiab nws qhov tshwj xeeb rau lub sijhawm ntev.

Qhov tseem ceeb ntawm qhov kev tawg no:

Nws tsis tsuas yog hais txog qhov kev sib tw ntev ntev hauv kev ua haujlwm ntawm bioprosthetic li qub, txuas ntxiv cov khoom lag luam, tab sis kuj tseem cuam tshuam cov txiaj ntsig tshiab rau hauv daim ntawv thov ntawm glutaraldehyde hauv cov khoom siv biomedical high-end.