Hauv kev cog cov hlab ntsha hauv lub plawv, glutaraldehyde tau siv ntev los kho cov nqaij ntawm cov tsiaj (xws li cov nyuj pericardium) rau kev tsim cov bioprosthetic valves. Txawm li cas los xij, cov pawg aldehyde dawb uas seem los ntawm cov txheej txheem ib txwm muaj tuaj yeem ua rau calcification tom qab cog, ua rau lub sijhawm ntev ntawm cov khoom tsis ruaj khov.
Txhawm rau daws qhov teeb meem no, kev tshawb fawb tshiab tshaj tawm thaum lub Plaub Hlis 2025 tau qhia txog kev kho mob tshiab tiv thaiv kev calcification (lub npe khoom: Periborn), ua tiav kev vam meej zoo kawg nkaus.
1. Kev Txhim Kho Txuj Ci Tseem Ceeb:
Cov kev daws teeb meem no qhia txog ntau yam kev txhim kho tseem ceeb rau cov txheej txheem sib txuas ntawm glutaraldehyde ib txwm muaj:
Kev Sib Txuas Lus ntawm Cov kuab tshuaj organic:
Glutaraldehyde cross-linking yog ua tiav hauv cov organic solvent uas muaj 75% ethanol + 5% octanol. Txoj hauv kev no pab tshem tawm cov phospholipids ntawm cov nqaij thaum lub sijhawm cross-linking - phospholipids yog cov chaw tseem ceeb rau kev calcification.
Tus Neeg Sawv Cev Rau Qhov Chaw:
Tom qab kev sib txuas, polyethylene glycol (PEG) yog siv los ua tus neeg sawv cev rau qhov chaw, nkag mus rau hauv qhov sib txawv ntawm collagen fibers. Qhov no ob qho tib si tiv thaiv cov chaw nucleation ntawm hydroxyapatite crystals thiab tiv thaiv kev nkag mus ntawm calcium thiab phospholipids los ntawm cov plasma tus tswv tsev.
Kev Kaw Qhov Kawg:
Thaum kawg, kev kho mob nrog glycine neutralizes cov seem, cov tshuaj aldehyde dawb, yog li tshem tawm lwm yam tseem ceeb uas ua rau calcification thiab cytotoxicity.
2. Cov Txiaj Ntsig Zoo Tshaj Plaws hauv Kev Kho Mob:
Cov thev naus laus zis no tau siv rau ntawm lub pob txha caj qaum ntawm cov nyuj hu ua "Periborn." Kev tshawb fawb soj ntsuam hauv tsev kho mob uas suav nrog 352 tus neeg mob tshaj 9 xyoos tau ua pov thawj tias tsis tas yuav rov ua dua vim muaj teeb meem cuam tshuam nrog cov khoom lag luam txog li 95.4%, lees paub qhov ua tau zoo ntawm txoj kev tiv thaiv calcification tshiab no thiab nws lub zog ntev.
Qhov Tseem Ceeb ntawm Qhov Kev Tshwm Sim No:
Nws tsis yog tsuas yog daws qhov teeb meem ntev hauv kev siv bioprosthetic valves, ua kom lub neej khoom ntev dua, tab sis kuj tseem txhaj tshuaj tshiab rau hauv kev siv glutaraldehyde hauv cov ntaub ntawv biomedical siab.
Lub sijhawm tshaj tawm: Lub Kaum Hli-28-2025