1. Kev Tsim Kho Tshiab hauv Kev Tshawb Fawb Txog Kev Tshawb Fawb
Kev tsim cov txheej txheem kuaj pom tseeb thiab ua tau zoo tseem yog qhov tseem ceeb hauv kev tshawb fawb txog sodium cyclamate, ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev nyab xeeb zaub mov.
Kev Siv Duab Hyperspectral Ua Ke Nrog Kev Kawm Tshuab:
Ib txoj kev tshawb fawb xyoo 2025 tau qhia txog kev siv tshuab nrhiav pom sai thiab tsis ua puas tsuaj. Txoj kev no siv cov duab ze-infrared hyperspectral imaging (NIR-HSI, 1000–1700 nm) los luam theej cov hmoov zaub mov miv thiab suav nrog cov chemometrics thiab cov algorithms kawm tshuab (piv txwv li, cov qauv partial least squares regression (PLSR) uas tau ua tiav nrog Savitzky-Golay smoothing) los ua kom tiav kev tshuaj xyuas ntau ntawm cov sodium saccharin thiab lwm yam khoom qab zib uas tsis raug cai ntxiv. Tus qauv tau tshaj tawm tias tau ua tiav qhov kev kwv yees ntawm kev txiav txim siab (R²) siab txog 0.98 thiab qhov yuam kev ntawm kev kwv yees (RMSEP) ntawm 0.22 wt%. Qhov no muab cov cuab yeej tshiab muaj zog rau kev saib xyuas zoo hauv online ntawm cov zaub mov tsiaj thiab lwm yam khoom noj nyuaj.
Kev Tsim Cov Qauv Sab Hauv Uas Muaj Cov Cim Isotope Ruaj Khov:
Txhawm rau txhim kho qhov tseeb thiab kev tiv thaiv kev cuam tshuam ntawm kev tshawb pom mass spectrometric, cov kws tshawb fawb tau tsim cov deuterium-labeled sodium cyclamate (isotope ruaj khov D-labeled sodium cyclamate) ua tus qauv sab hauv. Kev tsim cov tshuaj pib nrog cov dej hnyav (D₂O) thiab cyclohexanone, ua raws li cov kauj ruam hydrogen-deuterium pauv pauv, reductive amination, thiab sulfonylation kom thaum kawg tsim tetradeutero sodium cyclohexylsulfamate nrog deuterium isotope abundance tshaj 99%. Thaum siv ua ke nrog isotope dilution mass spectrometry (ID-MS), cov qauv sab hauv no ua rau muaj kev tseeb thiab kev ntseeg siab ntawm kev tshawb pom, tshwj xeeb tshaj yog rau kev lees paub thiab kev ntsuas qhov tseeb ntawm cov qib me me ntawm sodium cyclamate hauv cov qauv sib xyaw.
2. Kev Rov Ntsuam Xyuas Dua Txog Kev Nyab Xeeb thiab Kev Noj Qab Haus Huv
Kev nyab xeeb ntawm sodium cyclamate tseem yog qhov tseem ceeb ntawm kev tshawb fawb thiab pej xeem, nrog rau kev tshawb fawb tshiab txuas ntxiv tshawb nrhiav nws cov teebmeem kev noj qab haus huv.
Cov Cai thiab Kev Siv Tam Sim No:
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov cai tswjfwm sodium cyclamate tsis yog thoob ntiaj teb. Nws siv ua khoom noj khoom haus ntxiv raug txwv tsis pub siv hauv cov tebchaws xws li Tebchaws Meskas, United Kingdom, thiab Nyiv Pooj. Txawm li cas los xij, nws raug tso cai hauv cov tebchaws xws li Tuam Tshoj, txawm tias muaj kev txwv siab tshaj plaws (piv txwv li, GB2760-2011). Cov kev txwv no tau tsim los ntawm kev ntsuas kev nyab xeeb uas twb muaj lawm.
Kev Txhawj Xeeb Txog Tej Yam Yuav Ua Rau Muaj Kev Pheej Hmoo Hauv Kev Noj Qab Haus Huv:
Txawm hais tias cov txiaj ntsig tshawb nrhiav tsis tau qhia txog cov kev tshawb pom tshiab tseem ceeb hauv xyoo 2025 txog kev pheej hmoo kev noj qab haus huv tshwj xeeb rau sodium cyclamate nws tus kheej, kev tshawb fawb txog lwm yam khoom qab zib dag, sodium saccharin, yog qhov tseem ceeb. Siv tus qauv nas uas ua rau muaj tus kab mob polycystic ovary syndrome (PCOS), kev tshawb fawb pom tias sodium saccharin yuav ua rau muaj kev tsis zoo ntawm PCOS (piv txwv li, kev nyias nyias ntawm cov hlwb granulosa sab nraud, cov cysts nce ntxiv) thiab cov kab mob endocrine los ntawm kev ua kom cov receptors qab zib thiab iab hauv cov zes qe menyuam, cuam tshuam nrog cov yam ntxwv steroidogenic (xws li StAR, CYP11A1, 17β-HSD), thiab ua kom p38-MAPK/ERK1/2 apoptosis pathway ua haujlwm. Kev tshawb fawb no ua rau peb nco ntsoov tias cov teebmeem kev noj qab haus huv ntawm cov khoom qab zib dag, tshwj xeeb tshaj yog los ntawm kev noj mus sij hawm ntev thiab lawv cov teebmeem rau cov neeg mob tshwj xeeb, xav tau kev saib xyuas thiab kev kawm tob tob.
3. Cov Qauv Lag Luam thiab Cov Kev Taw Qhia Yav Tom Ntej
Kev ua lag luam thiab kev txhim kho ntawm sodium cyclamate kuj qhia txog qee qhov kev hloov pauv.
Tsav los ntawm Kev Xav Tau ntawm Kev Ua Lag Luam:
Kev ua lag luam qab zib dag, suav nrog sodium cyclamate, ib feem yog vim muaj kev thov thoob ntiaj teb los ntawm cov lag luam khoom noj, dej haus, thiab tshuaj rau cov qab zib uas tsis muaj calorie ntau thiab pheej yig. Tshwj xeeb tshaj yog nyob rau hauv qee lub tebchaws uas tseem tab tom txhim kho, sodium cyclamate tseem siv vim nws tus nqi qis thiab qab zib siab (kwv yees li 30-40 npaug qab zib dua li sucrose).
Cov Qauv Kev Loj Hlob Yav Tom Ntej:
Thaum ntsib teeb meem, kev lag luam sodium cyclamate yuav tsom mus rau kev txhim kho kev noj qab haus huv. Qhov no yuav suav nrog kev tshawb nrhiav kev txhim kho hauv cov qauv molecular thiab cov qauv los txhim kho nws cov biocompatibility thiab saj profile, ua rau nws ze rau cov suab thaj ntuj. Tib lub sijhawm, kev koom ua ke ntawm lub tswv yim ntawm kev noj zaub mov kom raug los tsim cov khoom lag luam uas ua tau raws li cov kev xav tau kev noj qab haus huv tshwj xeeb (piv txwv li, kev tswj hwm ntshav qab zib) kuj yog qhov kev taw qhia muaj peev xwm.
Zuag qhia tag nrho, kev tshawb fawb tshiab kawg ntawm sodium cyclamate qhia txog ob yam ntxwv tseem ceeb:
Ntawm ib sab tes, cov thev naus laus zis nrhiav tau tab tom nce qib mus rau qhov ceev dua, qhov tseeb dua, thiab qhov ua tau zoo dua. Cov thev naus laus zis tshiab, xws li kev sib xyaw ua ke ntawm kev thaij duab hyperspectral nrog kev kawm tshuab thiab kev siv cov qauv ruaj khov sab hauv isotope, tab tom muab cov cuab yeej muaj zog dua rau kev tswj hwm kev nyab xeeb zaub mov.
Ntawm qhov tod tes, kev txhawj xeeb txog nws cov teebmeem kev noj qab haus huv tseem muaj. Txawm hais tias cov ntaub ntawv tshuaj lom tsis ntev los no tshwj xeeb tshaj yog txog sodium cyclamate nws tus kheej tsis tshua muaj, kev tshawb fawb txog cov khoom qab zib cuav (piv txwv li, sodium saccharin) qhia tias yuav tsum tau ua tib zoo saib xyuas lawv cov teebmeem kev noj qab haus huv mus sij hawm ntev.
Lub sijhawm tshaj tawm: Cuaj hlis-15-2025